Bioperine or black pepper, which is a common spice, has medicinal properties. It is a tropical plant and India is the largest producer of Piper Nigrum. It possesses anti-bacterial and anti-inflammatory properties. It acts as an antioxidant agent also. Black Pepper contains essential oil, which acts against intestinal flatulence and also stimulates sweating and urination. The essential oil found in Piper Nigrum stimulates stomach cells to produce HCl acid, which helps in digestion. Piper Nigrum also helps in absorption of certain essential micronutrients like coenzyme Q-10, beta-carotene and EGCG. Pepper has its contribution in Ayurvedic medicines also. Pepper seeds are used to prepare sinusitis relieving medicines. It also used for sore throat and dry cough.

Caffeine is a methylated xenthine discovered in 1819 by Friedrich Ferdinand Runge, a German chemist. Sources of Caffeine include beans, fruit and leaves of some plants. Caffeine available for human consumption is most commonly extracted from the coffee plant cherries and tea bush leaves, as well as foods and drinks that contain products derived from the kola nut. Caffeine can temporarily reduce the sensation of being tired; however, this does not mean that it eliminates the need for sleep. Generally, twenty five to fifty milligrams of caffeine is enough for most consumers to report an increase in alertness and arousal. Caffeine should be not be consumed by those with fecal incontinence as it relaxes the internal anal sphincter muscles.

Guggulsterone is a plant sterol found in the resin of the guggul plant, Commiphora mukul. It acts as an antagonist of the farnesoid X receptor, which was earlier believed to result in decreased cholesterol synthesis in the liver.

Synephrine is a drug that is deemed to selectively bind to and also activate alpha adrenergic receptors. Mainly used as a vasoconstrictor in asthma, glaucoma, circulatory failure and nasal congestion, this compound is currently propagated as a weight loss agent. The alleged function synephrine is providing include fat burning, energy level and metabolism increase and promotion of weight loss. Synephrine, also known as oxedrine, is the widely accepted replacement for ephedrine. The natural source of synephrine is the citrus aurantium fruit, better known as bitter orange. Bitter orange extracts, which contain synephrine, are known to stimulate the alpha-1 adrenergic receptor, thereby constricting blood vessels and increasing the heart rate as well as blood pressure, effecting in an increased energy use.

Yohimbe is a tree that grows in different parts of Western Africa. Active compounds called alkolids are present in its bark with Yohimbine being the principal alkaloid. Yohimbe bark extracts are available in health food outlets. You can also buy it online. These extracts are promoted as a product that increases sex drive and for the treatment of erectile dysfunction. However, there is proof of their effectiveness. Most studies are concerned with the drug Yohimbine and not herbal extract Yohimbe. The side effects of Yohimbe include anxiety and dangerous increase in blood pressure.