Caffeine is the most widely used legal stimulant of the central nervous system and is also used in ThermaZyne, with characteristics that have been described as restoration of alertness and removing from drowsiness. Coffee, Tea, many soft drinks and energy drinks as well as nutrition supplements have this ingredient, which is a psychoactive substance, a xanthine alkaloid that can act as a adenosine receptor antagonist, as well as a phosphodiesterase inhibitor. Although regular use of caffeine seems to have nootropic effects, enhancing cognitive abilities, it also is known to provide long term effects on the nervous and cardiovascular system, like in one study it was proven that people with normal to low blood pressure have the possibility of developing a heart disease significantly reduced, as well as the chance of getting the Parkinson’s disease.

Citrus Aurantium, More commonly called "bitter orange", which is taken from unripe oranges. Research shows that citrus aurantium can increase the metabolic rate without affecting heart rate or blood pressure, breaks down fat, burns calories and may act as an appetite suppressant.

Synthetic Guggulsterones are derived from a herb, commiphora mukul, which has been proven to restore lagging metabolic rate brought about by dietary caloric deficiency, such as a diet low in carbohydrates. Though it has cholesterol lowering ability, it is also known as powerful weight loss agent due to the increased conversion of the inactive thyroid hormone T4 into its active part T3 in the liver. Furthermore, Guggulsterones are also known to stimulate the thyroid directly by enhancing TSH (Thyroid Stimulating Hormone) production. This is especially true for two specific guggulsterones codenamed Z and E.

Yohimbe is a powerful herb that has been used for many centuries. It comes from Corynanthe Yohimbe tree’s bark. These types of trees are found in West Africa. It can enhance sexual performance. It has many health benefits. Research has found that it is efficacious as sex marital therapy to revive sexual function. It is also beneficial in treatment of male organic impotence, particularly with that of diabetes. It is considered to be a powerful sexual stimulant. It is used as an aphrodisiac to enhance sexual desire. It has proved helpful in treating sexual dysfunction including erectile dysfunction, in men.