6,7 Dihydroxybergamottin is a furanocoumarin. This ingredient is generally present in grapefruit. It is also present in bergamot oil from which it derives its name. To a lesser extent it is even available in other citrus fruits and essential oils. Consuming 6, 7 dihydroxybergamottin supplements have an affect on the metabolism of various pharmaceutical drugs. 6, 7 Dihydroxybergamottin inhibits isforms of cytochrome P450 enzyme, especially CYP3A4. It is because of this feature that the enzyme prevents oxidative metabolism of some drugs, which results in accumulation of the drug in the bloodstream. According to some clinical studies 6, 7 dihydroxybergamottin hamper the body’s ability to digest caffeine, thereby extending its presence in the body. Patients under medication must therefore avoid consuming grapefruit and related supplements.

Caffeine is a central nervous system stimulant that temporarily wards off drowsiness and boosts alertness and energy.

Capsaicin is used in several skin preparations and is used to relieve pain. It is available in the market in various forms such as ointments, creams, gels, liquids, lotions, sticks and pads under marketing names such as Capsagel, Zostrix, Arthricare for Women and Icy Hot Arthritis Treatment. A very astonishing fact is that capsaicin happens to be the active part of chili peppers. Though it is an irritant producing burning sensation on any tissue that comes in contact with it, it depletes substance P. Substance P transmits impulses of pan to the brain. It relieves pain due to diseases such as osteoarthritis, diabetes neuropathy and rheumatic arthritis. Capsaicin has not had any drug interactions till date. But this does not means that it can never have any interaction with any other drug. It is always best to confirm with your doctor if you really need to use capsaicin. Also, it is best to use this drug only in specified quantities.

Yerba Matte- The plant of the yerba maté, as yerba matte is actually called, is a small tree or a shrub which can grow up to a size of fifteen meters. The leaves and twigs have traditionally been used to brew a tea like concoction, which is still a very popular social beverage in South America. Yerba maté contains alcaloids that are very similar to caffeine, commonly referred to as xanthines, but also elements like manganese, magnesium and potassium. The main difference between yerba maté and coffee, for instance, is the effect it has on muscle tissue, where it appears to relax smooth muscle tissue, but stimulate heart tissue and that is why it is used in Stacker 3 XPLC. In other studies, yerba maté was found to work as a monoamine oxidase inhibitor, thereby professing antidepressant qualities.

Yohimbine HCL is the active chemical component of the medicinal herb Pausinystalia yohimbe. It is a stimulant drug and is reportedly an aphrodisiac. According to the National Institute of Health (NIH), the standardised form of this chemical is Yohimbine hydrochloride (HCL) and is available as a prescription drug in the United States. Research has shown that yohimbine hydrochloride is effective as a treatment for male impotence. However while yohimbine HCL has been used as a prescription medicine to treat erectile dysfunction controlled studies suggests conflicting results. Apart from male sexual dysfunction, yohimbine HCL has also been used to treat the side effects of antidepressants like female hyposexual disorder etc. It is also used to recall memories in the treatment of post-traumatic-stress-disorder. While there are several uses for yohimbine HCL, there are several side effects too. These include high blood pressure, insomnia, panic attacks, hallucinations, headaches, renal failure, heart disease etc.