Dicaffeine Malate is actually a combination of caffeine and malic acid. Malic acid in turn is won out of Apple Juice and is a food additive with the E number E296. In green apples, the sour taste is due to malic acid. When cocaine was outlawed, The Coca-Cola Company introduced dicaffeine malate as the replacement. It is a stimulant, much like caffeine, but apparently gentler on the digestive tract. Many traits associated with regular caffeine are found in this caffeine salt, but through the interaction with malic acid, additional features have been observed. Dicaffeine malate is a very common ingredient in dietary supplements, it is supposed to optimize energy levels, increase mental focus and cognitive awareness, but also is able to stimulate thermogenesis.

Methylxanthines (Caffeine) is a naturally occurring stimulant. Active ingredients of cocoa, coffee, cola and tea - caffeine, theobromine and theophylline fall under this group. It relaxes bronchial muscles, dilates the constricted airways, relieves congestion and stimulates diuresis. They get properly absorbed and evenly distributed in the body. Methylxanthine is mostly prescribed for people suffering from chronic obstructive pulmonary disease (COPD) having serious breathing problems persistently, despite of using inhaled anticholinergic and inhaled beta2-agonist. However it is not given top priority while treating COPD because it is known to cause side-effects. Headache, stomach upset, insomnia, heartburn, rapid breathing and rapid heart rate are some of the side effects experienced by people who have taken methylxanthine. Nevertheless, these side effects can be reduced by staying away from caffeine.

PEA (Phenylethylamine), which is also known as Beta-Phenylethylamine, is a supplement, which favors aggression and is supposed to raise mental alertness, focus, and ability to concentrate. It is believed to also promote energy. In clinical trials it has been observed that infusion of Beta-Phenylethylamine raises the extracellular dopamine count, furthermore inhibiting the dopamine transmitter DA neuron firings. An additional activity is seen through the Beta-Phenylethylamine modulation of noradrenergic transmissions. It is viewed as a stimulant, but the lack or disturbed amounts of PEA have been observed in people with attention deficit and the hyperactivity disorders, people suffering from depression, schizophrenia, migraine and phenylketonuria. The obvious antidepressant qualities are paired with the increased wakefulness, which may lead to difficulty falling asleep, but improve motivation when exercising or training.

Synephrine HCL- Synephrine Hydro Chloride is commonly believed to have properties that assist is increasing the metabolic rate of the body and boost energy. It is similar to ephedrine and caffeine and stimulates the metabolism of fat without cardiovascular side effects. The supplement is used by athletes for building muscular mass through an increased metabolism in the body. Other than the aforementioned uses, it is used as a laxative and an aromatic expectorant. Synephrine HCL does have its side effects and it is advised that the supplement not be used for more than three days at a stretch. Because of its potency, it can lead to an increase in the heart rate, anxiety, rise in blood pressure, nervousness and an inability to urinate, which are dangerous complications.