Dicaffeine Malate is used as a replacement for caffeine in colas and dietary supplements. It boosts energy while being easier on the stomach.

Methylxanthines (Caffeine) is a naturally occurring stimulant. Active ingredients of cocoa, coffee, cola and tea - caffeine, theobromine and theophylline fall under this group. It relaxes bronchial muscles, dilates the constricted airways, relieves congestion and stimulates diuresis. They get properly absorbed and evenly distributed in the body. Methylxanthine is mostly prescribed for people suffering from chronic obstructive pulmonary disease (COPD) having serious breathing problems persistently, despite of using inhaled anticholinergic and inhaled beta2-agonist. However it is not given top priority while treating COPD because it is known to cause side-effects. Headache, stomach upset, insomnia, heartburn, rapid breathing and rapid heart rate are some of the side effects experienced by people who have taken methylxanthine. Nevertheless, these side effects can be reduced by staying away from caffeine.

PEA (Phenylethylamine) is a monoamine and alkaloid which functions as a trace amine, neurotransmitter or a neuromodulator. Phenylalanine, an amino acid, is the source from which phenethylamine, another name for PEA, is naturally biosynthesized through enzymatic decarboxylation. Compounds that are found in supplements in form of phenethylamines can be very diverse and include entactogens, anorectics, bronchodilators, hallucinogens, antidepressants and stimulants. Substituted phenethylamines are related to amphetamines, but also to dopamine, epinephrine, norepinephrine, phenylalanine and tyrosine. PEA is used by body builders and sportspeople mainly because of the stimulative effects as a neuromodulator, raising alertness, mood, concentration and focus. The additional stimulation of AMPA receptors, which boosts release of acetylcholine through the glutamatergic system, is an additional bonus of this popular supplement ingredient.

Synephrine HCL- Synephrine Hydro Chloride is commonly believed to have properties that assist is increasing the metabolic rate of the body and boost energy. It is similar to ephedrine and caffeine and stimulates the metabolism of fat without cardiovascular side effects. The supplement is used by athletes for building muscular mass through an increased metabolism in the body. Other than the aforementioned uses, it is used as a laxative and an aromatic expectorant. Synephrine HCL does have its side effects and it is advised that the supplement not be used for more than three days at a stretch. Because of its potency, it can lead to an increase in the heart rate, anxiety, rise in blood pressure, nervousness and an inability to urinate, which are dangerous complications.