Advanta ZAdvantra-Z is made from the extract of citrus aurantium, also known as the Chinese herb bitter orange BSN Thermonex uses Advantra-Z because it has shown many positive weight loss properties.

Caffeine is a methylated xenthine discovered in 1819 by Friedrich Ferdinand Runge, a German chemist. Sources of Caffeine include beans, fruit and leaves of some plants. Caffeine available for human consumption is most commonly extracted from the coffee plant cherries and tea bush leaves, as well as foods and drinks that contain products derived from the kola nut. Caffeine can temporarily reduce the sensation of being tired; however, this does not mean that it eliminates the need for sleep. Generally, twenty five to fifty milligrams of caffeine is enough for most consumers to report an increase in alertness and arousal. Caffeine should be not be consumed by those with fecal incontinence as it relaxes the internal anal sphincter muscles.

Diiodotyrosine, also known as DIT, is a drug used to treat hyperthyroidism and is often included in dietary supplements designed to increase the metabolism and burn fat. It is considered a synthetic anti-thyroid agent that is used to decrease the amount of hormones the thyroid produces. In some cases it produces a response more quickly than radioactive iodine therapy while not causing the thyroid gland permanent damage. Possible serious side effects of this drug are the suppression of bone marrow which can lead the patient to having a decreased number of blood leucocytes, bronchitis, hepatitis, jaundice, skin rashes, and/or syndromes that are similar to systemic lupus erythematosus.

Evodia Rutaecarpa has been used in China by the native medicine and herbology practitioners for centuries as a weight loss agent. The Tetradium plant, as it is also known, as well as the bee bee tree, is native to Asia and the chemical associated with the weight loss effect has been isolated as evodiamine. In trials on mice it has been proven that the uptake of fat was significantly reduced by the specimen receiving the Evodia Rutaecarpa extract. While human testing was never truly conducted, the use of Evodia Rutaecarpa extracts in weight loss products seems to prove the interaction with the uncoupling protein 1, or UCP1, also named thermogenin. The stimulation of thermogenin by Evodia Rutaecarpa extract leads to energy being burned as heat, burning excess calories and consequently stored fat.

Green Tea Extract increases energy expenditure and affects fat oxidation, which therefore promotes weight loss by increasing the body's metabolism.

L-Tyrosine, a non-essential amino acid that is used to build protein. It is a precursor dopamine, as well as a precursor to norepinephrine and epinephrine. The body makes L-Tyrosine from the amino acid phenylalanine. Since L-Tyrosine is a precursor of Dopamine, it may raise mental alertness, making it of great use in exercise programs.

Naringin, which is a citrus flavanoid that is found in grapefruit. Naringin is commonly used in energy supplements as it may extend the duration of the effects of caffeine.

Octopamine is a biogenic substance which is containing an amine group, apparently related to noradrenaline, which is a catecholamine functioning as both, neurotransmitter and a hormone. Similar to norepinephrine, which is another name for noradrenaline, octopamine may act as a stress hormone, triggering increased heart rate, energy consumption and blood flow, even the blood pressure. One side effect of octopamine is apparently the release of fat from the adipocytes, which are the fat cells where excess energy is being stored. This side effect prompted the use of octopamine as a dietary supplement aimed at weight loss, but used in combination with other stimulants. Octopamine has been discovered in the middle of the twentieth century, but the use as a fat removal agent is very recent.

Yerba Matte, actually yerba maté, as it is called in Brazil, or Ilex paraguariensis in Latin, is a small tree or a shrub which can grow to fifteen meters. It is found naturally in South America, mainly in south of Brazil, Argentina, Paraguay, Uruguay and Chile. Foliage is evergreen, and the flowers are rather small, additionally there is a smallish fruit of red color. A tea like brewing in warm water, not boiling, is a popular drink in the native area, similar social gathering is common, akin to tea time practice in the United Kingdom. Yerba matte has several xanthines alkaloids which are related to caffeine, but although chemically identical to caffeine the mate xanthine cocktail provides different results, for instance it relaxes smooth muscle tissue and stimulates heart tissue. Yerba Matte is a potent ingredient in BSN Thermonex.